Assistant Professor of Biology
Born and raised in South Jersey, Dr. Law is a Stockton University alumnus who joined the faculty at Stockton in 2017. His Ph. D. work was performed at the University of Southern California focusing on the biophysical properties underlying protein-RNA interactions. Following his Ph. D., Dr. Law returned to New Jersey as a postdoctoral researcher at UMDNJ where he investigated transient transcriptional control during yeast meiotic differentiation. This project was funded by an NIH National Research Scholar Award. Shortly after his postdoc, Dr. Law started his independent research laboratory focused on understanding the roles of histone methylation during yeast cell fate decisions.
B.S. Biology, Stockton University, 2000
Ph. D. Biochemistry and Molecular Biology, University of Southern California, 2006
AREAS OF EXPERTISE
Molecular Biology, Genetics, Genomics, Biochemistry
Cells & Molecules
Throughout their lifetimes, cells are constantly bombarded by an ever-changing environment. They integrate these environmental changes with information about themselves to make important decisions of cell fate. Mistakes in these processes can lead to developmental defects or cancer. Research in my laboratory is interested in understanding how cells integrate information about themselves and their environments to make the correct cell fate decision. Using the budding yeast S. cerevisiae as an experimental model, we are currently focusing on the roles of post-translational histone modifications in controlling yeast cell fates. To understand this question, we regularly employ genetic, molecular, biochemical, and genomic approaches.
Law, M. J. and M. A. Finger. 2017 The Saccharomyces cerevisiae Cdk8 mediator represses AQY1 transcription by inhibiting Set1p-dependent histone methylation. G3 (Bethesda) Mar 10;7(3):1001-1010.
Lardenois A., E. Becker, T. Walther, M. J. Law, B. Xie, P. Demougin, R. Strich, and M. Primig. 2015 Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification. Mol Genet Genomics. Oct; 290(5):2031-46.
Stuparevic I., E. Becker, M. J. Law, and M. Primig. 2015 The histone deacetylase Rpd3/Sin3/Ume6 compex repress an acetate-inducible isoform of VTH2 in fermenting budding cells. FEBS Letters Apr 2; 589(8): 924-32.
Liu Y., I. Stuparevic, B. Xie, E. Becker, M. J. Law, and M. Primig. 2015 The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1’s meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae. Mol Microbiol May; 96(4):861-74.
Becker E., Y. Liu, A. Lardenois, T. Walther, J. Horecka, I. Stuparevic, M. J. Law, R. Lavigne, B. Evrard, P. Demougin, M. Riffle, R. Strich, R. W. Davis, and M. Primig. 2015 Integrated RNA- and protein profiling of fermentation and respiration in diploid budding yeast provides insight into nutrient control of cell growth and development. J. Proteomics Apr 24;119:30-44.
Law M. J. and K. Ciccaglione. 2015 Fine-tuning of Histone H3 Lys4 Methylation During Pseudohyphal Differentiation by the CDK Submodule of RNA Polymerase II. Genetics Feb: 199(2): 631-42.
Lardenois A., I. Stuparevic, Y. Liu, M. J. Law, E. Becker, F. Smagulova, K. Waern, M. H. Guilleux, J. Horecka, A. Chu, C. Kervarrec, R. Strich, M. Snyder, R. W. Davis, L. M. Steinmetz, and M. Primig. 2014 The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Nucleic Acids Research 43(1): 115-28.
Law, M. J., M. J. Mallory, R. L. Dunbrack Jr. and R. Strich. 2014 Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast. Mol Cell Biol 34(4): 631-42.
Law, M.J., Lee D. S., Lee C. S., Anglim P. P., Haworth I. S., and Laird-Offringa, I.A. 2013. The role of the C-terminal helix in the interaction of U1A protein with U1hpII RNA. Nucleic Acids Research 41(14): 7092-100.
Mallory M.J.#, Law, M.J.#, Sterner D.E., Berger S.L., Strich R. 2012. Gcn5p-dependent acetylation induces
degradation of the meiotic transcriptional repressor Ume6p. Mol Biol Cell. 23(9):1609-17.
#equal contributions to manuscript
Cooper, K.F., Krasley E. Scarnati M.S., Mallory M.J., Jin C., Law M.J., Strich R. 2012. Oxidative stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction. J Cell Sci. 125:1015-26.
Mallory, M. J., M. J. Law, and R. Strich. 2010 Sin3p mediates the meiotic transcription program in yeast Euk. Cell 9:1835-1844.
Law, M.J., Rice, A.J., Lin, P., Laird-Offringa, I.A. 2006. The role of RNA structure in the interaction of U1A protein with U1hpII RNA. RNA 12: 1-11.
Law, M.J., Linde, M.E., Chambers, E.J., Oubridge, C., Katsamba, P.S., Nilsson, L., Haworth, I.S., Laird-Offringa, I.A. 2006. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res 34:275-285.
Law, M.J., Chambers, E.J., Katsamba, P.S., Haworth, I.S., Laird-Offringa, I.A. 2005. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56, and glutamine 54 network in the U1A/U1hpII interaction. Nucleic Acids Res 33:2917-2928.