Nathaniel W. Hartman
Associate Professor of Biology
|Website/CV:||Nathaniel Hartman Website|
B.A., Biology - Clark University, 2001 Ph.D., Biology - Wesleyan University, 2010 Postdoctoral Training - Yale University School of Medicine, Department of Neurosurgery
My background is in cellular neuroscience and molecular biology, with an expertise in developmental timing and stem cells. My graduate work at Wesleyan focused on the migration and integration of embryonic stem cell-derived neural progenitors transplanted into the hippocampus. My postdoctoral work involved cellular and molecular analysis of the mTOR pathway in postnatal neurogenesis in mice. My current research goals are to investigate neural development and to mentor and train the next generation of neuroscientists. I draw upon my research experiences in classes to help the students engage with the material on a regular basis. I try to help students understand that science is a process that is constantly updating our overall understanding of the natural world. My laboratory is currently pursuing projects aimed at elucidating mechanisms of neural stem cell fate decisions in mice, focusing on the Akt and mTOR pathways.
Ph.D., Wesleyan University
B.A., Clark University
AREAS OF EXPERTISE
Neurobiology, Developmental Biology, Stem Cells
Principles of Physiology
Stem Cells and Society
Molecular mechanisms of neural stem cell fate decisions
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. In press.
Hartman NW, Lin TV, Zhang, L, Paquelet GE, Feliciano DM, Bordey A (2013) mTORC1 targets the translational repressor 4E-BP2, but not S6 Kinase 1/2, to regulate neural stem cell self-renewal in vivo. Cell Reports 5(2): 433-444.
Feliciano DM, Hartman NW, Lin TV, Bartley C, Kubera C, Hsieh L, Lafourcade C, O’Keefe RA, Bordey A (2013) A circuitry and biochemical basis for Tuberous Sclerosis symptoms: From Epilepsy to Neurocognitive deficits. Int J Dev Neurosci. 31(7):667-678.
Germain ND, Hartman NW, Cai C, Becker S, Naegele JR, Grabel LB (2012) Teratocarcinoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. Cell Transplant. 21(8): 1603-11.
Lacar B, Herman P, Hartman NW, Hyder F and Bordey A. (2012) S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone. PLoS One 7(2): e31960.
Hartman NW, Grabel LB and Naegele JR (2011) Migration of Transplanted Neural Stem Cells in Experimental Models of Neurodegenerative Diseases. In: Stem Cells and Regenerative Medicine. Springer Press, Part 3, 315-336.
Hartman NW, Carpentino JE, LaMonica K, Mor DE, Naegele JR and Grabel L (2010) CXCL12-mediated guidance of migrating embryonic stem cell-derived neural progenitors transplanted into the hippocampus. PLoS One 5(12): e15856.
Ammon N, Hartman NW and Grabel L (2010) Directing differentiation of embryonic stem cells into distinct neuronal subtypes (Ulrich H, ed.). In: Perspectives of Stem Cells: From tools for studying mechanisms of neuronal differentiation towards therapy. Springer Press, 97-114.
Carpentino JE, Hartman NW, Grabel LB and Naegele JR (2008) Region-specific differentiation of embryonic stem
cell-derived neural progenitor transplants into the adult mouse hippocampus following
seizures. J Neurosci Res 86(3):512-24